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  1. #12
    killbarney's Avatar
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    Re: They are wanting to make the HPV vaccine mandatory in schools

    DES was proclaimed to be safe-ha!

    Vioxx was proclaimed to be safe-ha!

    Bextra was proclaimed to be safe-ha!

    And a big etc.

    There are NO long term studies to find out what will happen long term.

    As a society we wonder why some diseases are on the rise-more and more cancer(and yes, some of it is because of better detection), Alzheimers, etc. Is it possible that we are doing this to ourselves?


    ETA-and here you go.

    http://www.cancer.gov/clinicaltrials...er-vaccine1102

    Three shots

    The study involved 2,392 women from 16 to 23 years in age. Participants were randomly assigned to receive three shots of either an HPV-16 vaccine or a placebo (a dummy substance-I've found reference to the fact that it wasn't a normal "placebo" but another vaccine, am double checking). The study was double-blinded -- that is, neither the investigators nor the study participants knew who got the vaccine and who got the placebo. Participants were followed for an average of 17 months after getting the third shot.

    Some women had HPV-16 infections or other cervical abnormalities when they enrolled in the study; others developed the infection before they received all three shots. These women (859 enrollees) were excluded when the researchers calculated the vaccine’s effectiveness.

    Of the remaining 1,533 women, 41 developed HPV-16 infection -- all of these women were in the placebo group. Nine of the 41 women with HPV-16 infection went on to develop precancerous lesions (areas of abnormal tissue that may become cancerous). Twenty-two other women from the placebo group also developed precancerous lesions on their cervixes, but these were not associated with HPV-16.

    By comparison, no one who got all three vaccine shots developed an HPV-16 infection. Twenty-two women receiving the vaccine did develop cervical abnormalities that can lead to cancer but these precancerous lesions were not associated with HPV-16.
    http://www.fda.gov/bbs/topics/NEWS/2006/NEW01385.html

    ... Gardasil was evaluated and approved in six months under FDA's priority review process--a process for products with potential to provide significant health benefits....The safety of the vaccine was evaluated in approximately 11,000 individuals...manufacturer has agreed to conduct several studies following licensure, including additional studies to further evaluate general safety and long-term effectiveness(sounds like asking the fox to guard the hen house). The manufacturer will also monitor the pregnancy outcomes of women who receive Gardasil while unknowingly pregnant. Also, the manufacturer has an ongoing study to evaluate the safety and effectiveness of Gardasil in males(whatever on earth for-it's stated that they are using it to reduce CERVICAL cancer lol? eta-yes, I know men get HPV, I was being sarcastic).
    Last edited by killbarney; 01-26-2007 at 11:09 PM.
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  3. #13
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    Re: They are wanting to make the HPV vaccine mandatory in schools

    Quote Originally Posted by killbarney View Post
    DES was proclaimed to be safe-ha!

    Vioxx was proclaimed to be safe-ha!

    Bextra was proclaimed to be safe-ha!

    And a big etc.

    There are NO long term studies to find out what will happen long term.

    As a society we wonder why some diseases are on the rise-more and more cancer(and yes, some of it is because of better detection), Alzheimers, etc. Is it possible that we are doing this to ourselves?
    Not to mention Autism and some allergies.....vaccines are suspect in so many cases...

    Admittedly, I do need to look into HPV more as I'm really not familiar with the 'disease'.....I'm just very cautious about rushing into 'vaccines' and such, especially with my children.
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    Re: They are wanting to make the HPV vaccine mandatory in schools

    I'm researching it, too. I will not do anything until I understand it better.

    Quote Originally Posted by pepperpot View Post
    Not to mention Autism and some allergies.....vaccines are suspect in so many cases...

    Admittedly, I do need to look into HPV more as I'm really not familiar with the 'disease'.....I'm just very cautious about rushing into 'vaccines' and such, especially with my children.
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    Re: They are wanting to make the HPV vaccine mandatory in schools

    http://en.wikipedia.org/wiki/HPV_vaccine

    For example, some critics have claimed the studies on the vaccine are inadequate, as at least some of the research is done not using a real placebo group for comparison, but an aluminum-containing shot or another vaccine against a different disease. Also, at least in some studies, adverse events were actively followed only for 15 days.

    http://www.jabs.org.uk/pages/article3.doc

    HPV – Cervical Cancer Vaccine
    15 September 2006
    By Suzanne Nelson
    Honesthuman.com

    Next month the Joint Committee on Vaccination and Immunisation is set to determine whether pre-adolescent girls in the U.K. will receive a vaccine for a sexually transmitted disease at primary school.

    The vaccine, Gardasil, marketed by Sanofi Pasteur MSD, was approved for use in women by British authorities in July, and by the end of the year GlaxoSmithKline's version, Cervarix, is likely to be available. Both target human papillomavirus (HPV), a virus transmitted exclusively by sexual contact that in rare cases leads to cervical cancer.

    Paralleling a similar debate in the United States, much of the controversy about putting the vaccine on the childhood schedule has been about whether doing so will give youngsters a false sense of safety and lure them into promiscuous sex.

    Yet in the process of engaging that discussion, we're not talking about whether giving the vaccine to pre-adolescent girls makes sense in terms of their overall health, the long-term safety of the vaccine or whether it should be given in school -- all subjects much more controversial than news coverage would have you believe.

    HPV is not a virus a kid catches by sitting next to someone at school. It is not spread by sharing juice boxes or trading germs on the bus.

    That makes this vaccine completely different from the 10 others on the U.K.'s childhood vaccination schedule.

    This vaccine aims to protect people from a virus that is basically only transmitted when a person engages in what amounts to optional behaviour. HPV is not a public health threat in the same way, say, polio or measles are. And that gives governments much less of a compelling interest to mandate that children be vaccinated for it.

    Let's put aside for the purposes of discussion the bizarrely controversial notion that parents should be able to decide what enters their children's body via injection, especially when that shot carries the risk of harm or death.

    HPV does not lurk in the air, in swimming pools or on playground equipment. That makes the vaccine's public health credentials dubious at best.

    Yes, 3,000 women in the U.K. contract cervical cancer every year, and a third of them die. But just having HPV doesn't mean you're going to get cancer. The U.S. Food and Drug Administration said as much in its press release announcing the approval of Gardasil: "For most women, the body's own defense system will clear the virus and infected women do not develop related health problems."

    Estimates of the number of people with HPV vary wildly, but perhaps up to 80 percent of women in the United States, for example, are infected with HPV at one time or another before they are 50. Yet given that high incidence, the number of women who develop cervical cancer in the U.S. is pretty low, about 10,000 cases each year. Pap smears usually catch abnormal cells before cancer has progressed, when women are treated with extraordinarily high rates of success.

    The greatest risk factor for cervical cancer is not being screened or being screened at intervals greater than 5 years.

    That's not to say that it's not painful or tragic for thousands of women, but it's nonetheless relatively rare. There's a reason that just about every prediction about a reduction in cervical cancer due to the HPV vaccine is reported as a worldwide statistic. The numbers in the U.K. are just not that high as a percentage of the population. The same is true in the U.S., where cervical cancer is listed as a rare disease by the National Institutes of Health.

    Most women who develop invasive cervical cancer have not had regular pap smears. So to say that because 1,000 women in the U.K. die of cervical cancer every year, and there is thus an urgent public-health need to vaccinate every adolescent girl -- without mentioning that many if not most of those women did not have regular screenings -- is somewhat disingenuous.

    But even if the vaccine proves to be successful at reducing overall HPV infection, and the reduced number of HPV infections lead to a correlating decline in cervical cancer cases -- both still huge assumptions at this point, as the vaccine hasn't been studied nearly long enough to determine that -- some parents still may not want to give it to their daughters.

    For starters, it could cause harm. All vaccines carry the risk of injury or death. During trials, nine individuals developed arthritis after receiving the vaccine versus three for the placebo, out of approximately 21,000 individuals in that trial. Nine kids with arthritis after receiving the vaccine might not seem like a big deal in the grand scheme of things. After all, arthritis is better than cancer, right? That depends.

    Given the fact that cervical cancer is relatively rare, highly preventable and most often successfully treated early on, maybe the risk of arthritis -- a painful and often debilitating disease -- isn't a worthwhile trade-off.

    And maybe we won't know the true incidence of harmful effects until the vaccine is given to millions, rather than thousands, of children and young adults.

    Moreover, the whole concept of a placebo was turned on its head during the trials, preventing any valid comparison between those who were given a placebo and those who received the vaccine.

    In order to learn the truth about an unknown, honest science dictates that we have to compare it to a known. When most people think about a vaccine placebo, they are probably thinking about saline. But that's not what was used during trials.

    The "placebo" in this case was an aluminium-containing shot. The vaccine itself also contains aluminium.

    Aluminium hydroxide is what's known as an adjuvant — it stimulates immune response. Studies in both animals and humans have found that aluminium adjuvants can cause death of brain cells. Similar studies have also shown that aluminium adjuvants in vaccines can cross the blood-brain barrier, as well as cause injection-site inflammation leading to chronic joint and muscle pain and fatigue.
    Aluminium adjuvants have never been subjected to clinical trials for safety. Read that again: Although the metal has been used in vaccines for decades, it has never been rigorously studied for long-term safety.

    So perhaps the 1 case of lupus and 2 cases of arthritis out of 9,701 participants who received the "placebo" were not just statistical anomalies. Maybe it was the aluminium. Perhaps that would also explain the 1 case of juvenile arthritis, 2 cases of rheumatoid arthritis, 5 cases of arthritis and 1 case of reactive arthritis in 11,813 Gardasil recipients. We'll never know. (Some of the trial participants did, in fact, receive straight saline but there's no way to tell from the data released which cases are which.)

    More importantly, a reactive placebo artificially decreases the appearance of danger of an experimental vaccine in a clinical trial because the drug company only has to prove that adverse events weren't statistically significant in the vaccine group versus the placebo group. So using aluminium-containing placebos falsely inflates the adverse-event data of the "placebo" group, making the vaccine look relatively safe by comparison.

    Gardasil contains 225 mcg of aluminium. Neither Merck nor the U.S. FDA would answer my questions as to how much aluminium was used in the placebo. (Sanofi Pasteur MSD is marketing the vaccine in Europe and is a joint venture of French company Sanofi Pasteur and U.S. pharmaceutical company Merck.)
    Continued next post
    Last edited by killbarney; 01-26-2007 at 11:29 PM.
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  6. #16
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    Re: They are wanting to make the HPV vaccine mandatory in schools

    Rest of article

    Clinical trial investigators dismissed most of the 102 serious adverse events including 17 deaths that occurred in the clinical trials as unrelated to the study. But given the reactivity profile of aluminium, can we really say that for sure?

    Nearly 90 percent of all Gardasil recipients and 85 percent of those who received the "placebo" reported one or more adverse events within 15 days of vaccination. Pain and swelling at the site of injection affected approximately 83 percent of Gardasil recipients and 73 percent of those who received the aluminium placebo. About 60 percent of those who received either the vaccine or the placebo had systemic adverse events including headache, fever, nausea, dizziness, vomiting, diarrhoea and myalgia. Those who received the vaccine reported even more serious adverse events such as gastroenteritis, appendicitis, pelvic inflammatory disease, asthma, bronchospasm and arthritis.
    In a never before done study, scientists recently found a link between aluminium in vaccines and symptoms associated with Parkinson's, amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease) and Alzheimer's.

    "This is suspicious," neuroscientist Chris Shaw told the Georgia Straight, Canada's largest urban weekly. "Either this [link] is known by industry and it was never made public, or industry was never made to do these studies by Health Canada. I'm not sure which is scarier."

    Shaw said there could be 10,000 studies showing aluminium hydroxide is safe to be injected, but that he hasn't been able to find one study that looked beyond the first few weeks of injection. The reason this is significant, according to Shaw, is that neurological damage can take years to manifest.

    Indeed, this is what we see time and again in vaccine studies. Either the placebo itself contains aluminium, which doesn't much allow us to learn the reactivity profile of the experimental vaccine, or the participants are only monitored for safety issues for a small frame of time, or, as in the case of Gardasil, both.

    What Shaw and his colleagues found was neuron death. That's no small thing, as it's implicated in hundreds of medical conditions. If someone has a controlled, long-term study that shows aluminium hydroxide is safe, he said, please "put it on the table. That's how you do science."

    Participants in the Gardasil studies were monitored for, at most, four years and many for a considerably shorter time frame. The largest trial is scheduled to be ended early and the people who were given a placebo now will be given the vaccine, meaning it's no longer possible to study long-term differences in health between those who received the vaccine and those who received the placebo.

    In terms of long-term safety, one sentence in the FDA's insert is particularly revealing. "Gardasil has not been evaluated for the potential to cause carcinogenicity or genotoxicity," according to the insert. Yes, carcinogenicity means the ability to cause cancer. It's also not known whether the vaccine can cause chromosomal damage. We don't know because researchers didn't look. The trials were not set up to examine that question.

    The vaccine is approved for use in girls as young as nine. The rationale for doing so is that the vaccine is only effective prior to exposure to HPV and actually leads to increased risk of precursors to cervical cancer in those previously infected, so it's best to catch girls as early as possible. Yet only 100 9-year-olds received Gardasil in trials, adding to the unknowns about administering a vaccine on still developing bodies. Those children have only been followed for 18 months.

    If this vaccine turns out to have safety issues are we even going to know? Or will it remain on the childhood vaccinations schedule long after many girls suffer serious side effects or worse?

    Even more terrifying is the idea -- being put forth by some HPV vaccine proponents -- of giving the vaccine to toddlers so as to weaken the possible connection between a vaccine for a sexually transmitted disease and "promiscuous" behaviour by youngsters.

    Dr. Anne Szarewski, a consultant for Cancer Research UK who worked on the vaccine trials, told The Telegraph that giving the shot to young children was a good idea, provided that its efficacy could be proved to last into adulthood.

    "There is an argument to giving it to toddlers, because you get away from any links between sexual activity and the whole ethical question that it poses," Szarewski said.

    Even entertaining the idea of giving the vaccine to 2- and 4-year-olds is ludicrous at this stage give that the trials have thus far lasted well short of a decade, and we have no idea how a toddler's immune system would cope.

    We do know generally that vaccines stimulate qualitatively inferior immunity than natural exposure, and for this reason most vaccines are "boosted" periodically during childhood or adolescence. Naturally acquired immunity lasts much longer, perhaps even a lifetime. The vast, vast majority of people who contract HPV pass the virus without symptoms.

    Even if we're talking about vaccinating 9- to 12-year-olds, we still have no reason to believe at this point that the duration of immunity would last that long or until their first sexual encounter.

    Dr. Clayton Young, a board-certified obstetrician gynaecologist in Texas, outlined his objections this way: "Vaccinating these children against HPV with a vaccine that is of unknown duration of efficacy will only postpone their exposure to an age which they are less likely [to] clear the infection on their own and be subject to more severe disease.

    "The study of the vaccine in children and adolescents is limited to only measuring the development of antibodies to the HPV subtypes in the vaccine," Young continued. "There is absolutely no evidence that the vaccine prevents anything when administered at this young age. Merck expects you to extrapolate their adult data to the immune response in children. If they were really interested in vaccine efficacy in children, should it not be studied properly in children?"

    Sanofi Pasteur and Merck have an enormous amount at stake in the universal administration of the shots.(GEE-WHAT A COINCIDENCE, MERCK SUBSIDIZED THE STUDIES) A place on the childhood vaccination schedule means a steady and exponentially larger revenue stream. Financial analysts predict Gardasil could be Merck's most important pipeline contributor to top-line growth, with peak sales of at least $2 billion -- revenue Merck badly needs after the Vioxx scandals. That revenue figure assumes that Gardasil will be required for school admittance.

    "It's a stockholders dream," said Barbara Loe Fisher, president of the NVIC, a U.S. non-profit organisation that promotes the right to informed consent on vaccine decisions. Fisher sat on the FDA's committee that reviews vaccines in 2001, when the vaccine underwent early reviews.

    Fisher went on to explain that Merck did not reveal in public documents exactly how many 9- to 15-year-old girls were in the clinical trials and how many of them had serious adverse events after being injected with Gardasil or the aluminium-containing placebo. "For example, if there were fewer than 1,000 little girls actually injected with three doses of Gardasil, it is important to know how many had serious adverse events and how long they were followed for chronic health problems, such as juvenile arthritis.

    "This has nothing to do with kids and whether they are going to have sex," Fisher added. "It has to do with whether they are going to be set up for chronic inflammatory disease" from yet another vaccine being added to the litany of those they already receive. "I would want more data on long-term effects of autoimmunity on certain genotypes," she said in an interview, "and whether this vaccine is going to harm far more girls than it is going to protect."

    Dr. Jacqueline Laing, a specialist in medical ethics at London Metropolitan University, was equally as critical: "Diseases associated with promiscuity will never be eradicated by universal state vaccination," she told The Telegraph. "The interests of the vaccine manufacturers should not take precedence over the rights and safety of children."


    Suzanne Nelson is a freelance journalist and writer living in New Orleans. She spent five years covering the U.S. Congress for Roll Call Newspaper in Washington, D.C., and now focuses on subjects pertaining to health. She also maintains a health blog at honesthuman.com.
    Last edited by killbarney; 01-26-2007 at 11:35 PM.
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    Re: They are wanting to make the HPV vaccine mandatory in schools

    I have mixed feelings on this. Plus I have boys and it isn't a huge issue for us. I am not real fond of any vaccine period. I know there are huge benefits from vaccines, but there are also huge risks associated with getting them. I agree there isn't enough long term studies to get in line for this vaccine. I think if it truly does work and there are less doubts then I think this is a fabulous vaccine and would encourage people to get them.
    As far as free clinics giving them, if they become mandatory, then the health dept. will definatly offer them. I think most would be surprised at the cost of the vaccines already mandatory.
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    Re: They are wanting to make the HPV vaccine mandatory in schools

    I believe that's plain stupid. Might as well give them a buncha condoms since that is safer than a vaccinne from OTHER STDS etc they can all get. That vaccinne is certainly not going to prevent every other STD, pregnancy, etc. you could get out there so I see no need for it and no need for it to be required in SCHOOL. That is just ridiculous. Just use common sense and condoms or abstain and at least be smart about it and make sure the other person doesn't have a disease. I don't see how hard it is to have the other person checked out to avoid any disease altogether.

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    Re: They are wanting to make the HPV vaccine mandatory in schools

    Quote Originally Posted by silvermist View Post
    I believe that's plain stupid. Might as well give them a buncha condoms since that is safer than a vaccinne from OTHER STDS etc they can all get. That vaccinne is certainly not going to prevent every other STD, pregnancy, etc. you could get out there so I see no need for it and no need for it to be required in SCHOOL. That is just ridiculous. Just use common sense and condoms or abstain and at least be smart about it and make sure the other person doesn't have a disease. I don't see how hard it is to have the other person checked out to avoid any disease altogether.
    I dont know how old you are,when you started having sex,or if you were a virgin when you got married(its none of my business)but please go back and think about what you wrote.When you are in the heat of the moment you arent going to stop the other person and ask if they have any STDs,of course they wont tell you if they do.Also you arent going to stop in the heat of the moment and tell the other person they need to get tested before you will have sex with them.Abstaining is a joke.I didnt know many people when I was a teen that was still a virgin.These are all thing we wish children and teens would do but the majority of the time its not going to happen.People dont think before they act and we all make mistakes.No I wasnt a virgin when I got married and I did some stupid stuff in my past thats why I know what you are saying just isnt the norm.As far as condoms go.You can give condoms to them but who is to say they will use them.Plus if condoms and Abstaining really worked all the time then we wouldnt have teen pregnancies and STDs would be dying out.
    Last edited by tammy77; 01-27-2007 at 01:38 PM.

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    Re: They are wanting to make the HPV vaccine mandatory in schools

    Can you see health departments offering that free of charge?
    The health dept where I live is charging ten dollars. I called about this a few days ago to see if it was offered. I looking into the vaccine for my daughter.

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    Re: They are wanting to make the HPV vaccine mandatory in schools

    Quote Originally Posted by BlueBerriTerri View Post
    My 8 year old just had a physical exam yesterday. You'd better believe that when she turns 9, she will be getting the vaccine. HPV is prevalent, easy to get, and there is no cure. Cervical cancer aside, it can also cause really ugly grapelike clusters of fleshy warts. I didn't know that by age 50, 80% of women have been infected with HPV. Most people don't even know that they have it. I will certainly take this opportunity to protect her from getting something in the future that could cause cervical cancer.
    I totally agree with you!!

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    Re: They are wanting to make the HPV vaccine mandatory in schools

    Most of us took our children to be vaccinated for the typical childhood illnesses and never questioned our physician. We knew we didn't want our child to die of a horrid disease. As a matter of fact, we immunize our children against mumps and measles, not exactly death sentences. Because this particular one has to do with sex, all of the sudden it seems there are a lot of folks who do find it acceptable for their kids to die of cervical cancer. While their daughters are lying in a hospice dying, their mothers can proudly say that they didn't encourage them to have sex by offering protection. None of us want promiscuous children, but they are human and will do what humans do. Is it right to let them die simply because we don't approve of their choices? We are talking about adolescents, and I don't know very many who can make choices in the same manner as an adult. As parents, it is our job to protect them. Stop and think about it. Maybe we don't give our daughter the vaccine, and continue to teach abstinence. Maybe she listens, and is a virgin on her wedding night. Maybe the man she marries has HPV.
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